Frontal and associative visual areas related to visual hallucinations in dementia with Lewy bodies and Parkinson's disease with dementia
Identifieur interne : 000970 ( Main/Corpus ); précédent : 000969; suivant : 000971Frontal and associative visual areas related to visual hallucinations in dementia with Lewy bodies and Parkinson's disease with dementia
Auteurs : Cristina Sanchez-Castaneda ; Ramon Rene ; Blanca Ramirez-Ruiz ; Jaume Campdelacreu ; Jordi Gascon ; Carles Falcon ; Matilde Calopa ; Serge Jauma ; Montserrat Juncadella ; Carme JunqueSource :
- Movement Disorders [ 0885-3185 ] ; 2010-04-15.
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Abstract
Visual Hallucinations (VH) are among the core features of Dementia with Lewy Bodies (DLB), but are also very frequent in demented patients with Parkinson's Disease (PDD). The purpose of this study was to investigate the pattern of gray matter and cognitive impairment underlying VH in DLB and PDD. We applied voxel‐based morphometry and behavioral assessment to 12 clinically diagnosed DLB patients and 15 PDD patients. Subjects with VH showed greater gray matter loss than non‐hallucinators, specifically in the right inferior frontal gyrus (BA 45) in the DLB patients and in the left orbitofrontal lobe (BA 10) in the PDD patients. Comparing the two subgroups with VH, DLB patients had greater decrease of the bilateral premotor area (BA 6) than PDD patients. Furthermore, decreased volume in associative visual areas, namely left precuneus and inferior frontal lobe, correlated with VH in the DLB but not in PDD patients. VH were related to impaired verbal fluency, inhibitory control of attention and visuoperception in the DLB group and to visual memory in the PDD group. In conclusion, DLB and PDD patients with VH had more frontal gray matter atrophy than non‐hallucinators, the impairment being greater in the DLB group. The patterns of structural and functional correlations were different in both pathologies. © 2010 Movement Disorder Society
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DOI: 10.1002/mds.22873
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The purpose of this study was to investigate the pattern of gray matter and cognitive impairment underlying VH in DLB and PDD. We applied voxel‐based morphometry and behavioral assessment to 12 clinically diagnosed DLB patients and 15 PDD patients. Subjects with VH showed greater gray matter loss than non‐hallucinators, specifically in the right inferior frontal gyrus (BA 45) in the DLB patients and in the left orbitofrontal lobe (BA 10) in the PDD patients. Comparing the two subgroups with VH, DLB patients had greater decrease of the bilateral premotor area (BA 6) than PDD patients. Furthermore, decreased volume in associative visual areas, namely left precuneus and inferior frontal lobe, correlated with VH in the DLB but not in PDD patients. VH were related to impaired verbal fluency, inhibitory control of attention and visuoperception in the DLB group and to visual memory in the PDD group. In conclusion, DLB and PDD patients with VH had more frontal gray matter atrophy than non‐hallucinators, the impairment being greater in the DLB group. The patterns of structural and functional correlations were different in both pathologies. © 2010 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Cristina Sanchez‐Castaneda MSc</name><affiliations><json:string>Dementia Unit, Department of Neurology, Bellvitge University Hospital, Barcelona, Spain</json:string><json:string>Department of Psychiatry and Clinical Psychobiology, University of Barcelona, IDIBAPS, Barcelona, Spain</json:string></affiliations></json:item><json:item><name>Ramon Rene PhD</name><affiliations><json:string>Dementia Unit, Department of Neurology, Bellvitge University Hospital, Barcelona, Spain</json:string></affiliations></json:item><json:item><name>Blanca Ramirez‐Ruiz PhD</name><affiliations><json:string>Department of Psychiatry and Clinical Psychobiology, University of Barcelona, IDIBAPS, Barcelona, Spain</json:string></affiliations></json:item><json:item><name>Jaume Campdelacreu PhD</name><affiliations><json:string>Dementia Unit, Department of Neurology, Bellvitge University Hospital, Barcelona, Spain</json:string></affiliations></json:item><json:item><name>Jordi Gascon MD</name><affiliations><json:string>Dementia Unit, Department of Neurology, Bellvitge University Hospital, Barcelona, Spain</json:string></affiliations></json:item><json:item><name>Carles Falcon PhD</name><affiliations><json:string>Image Analysis Unit, IDIBAPS, CIBER‐BBN, Physiological Science Department, University of Barcelona, Barcelona, Spain</json:string></affiliations></json:item><json:item><name>Matilde Calopa PhD</name><affiliations><json:string>Movement Disorders Unit, Department of Neurology, Bellvitge University Hospital, Barcelona, Spain</json:string></affiliations></json:item><json:item><name>Serge Jauma MD</name><affiliations><json:string>Movement Disorders Unit, Department of Neurology, Bellvitge University Hospital, Barcelona, Spain</json:string></affiliations></json:item><json:item><name>Montserrat Juncadella PhD</name><affiliations><json:string>Dementia Unit, Department of Neurology, Bellvitge University Hospital, Barcelona, Spain</json:string></affiliations></json:item><json:item><name>Carme Junque PhD</name><affiliations><json:string>Department of Psychiatry and Clinical Psychobiology, University of Barcelona, IDIBAPS, Barcelona, Spain</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>visual hallucinations</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>dementia</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Lewy Body disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>MRI</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>VBM</value></json:item></subject><articleId><json:string>MDS22873</json:string></articleId><language><json:string>eng</json:string></language><abstract>Visual Hallucinations (VH) are among the core features of Dementia with Lewy Bodies (DLB), but are also very frequent in demented patients with Parkinson's Disease (PDD). The purpose of this study was to investigate the pattern of gray matter and cognitive impairment underlying VH in DLB and PDD. We applied voxel‐based morphometry and behavioral assessment to 12 clinically diagnosed DLB patients and 15 PDD patients. Subjects with VH showed greater gray matter loss than non‐hallucinators, specifically in the right inferior frontal gyrus (BA 45) in the DLB patients and in the left orbitofrontal lobe (BA 10) in the PDD patients. Comparing the two subgroups with VH, DLB patients had greater decrease of the bilateral premotor area (BA 6) than PDD patients. Furthermore, decreased volume in associative visual areas, namely left precuneus and inferior frontal lobe, correlated with VH in the DLB but not in PDD patients. VH were related to impaired verbal fluency, inhibitory control of attention and visuoperception in the DLB group and to visual memory in the PDD group. In conclusion, DLB and PDD patients with VH had more frontal gray matter atrophy than non‐hallucinators, the impairment being greater in the DLB group. 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No. 2005 SGR 00855;</note><note>Generalitat de Catalunya</note><note>Center of Biomedic Investigation in Neurodegenerative Diseases (CIBERNED)</note><note>Biomedical Investigation Institute from the Bellvitge University Hospital</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Frontal and associative visual areas related to visual hallucinations in dementia with Lewy bodies and Parkinson's disease with dementia</title><author><persName><forename type="first">Cristina</forename><surname>Sanchez‐Castaneda</surname></persName><roleName type="degree">MSc</roleName><affiliation>Dementia Unit, Department of Neurology, Bellvitge University Hospital, Barcelona, Spain</affiliation><affiliation>Department of Psychiatry and Clinical Psychobiology, University of Barcelona, IDIBAPS, Barcelona, Spain</affiliation></author><author><persName><forename type="first">Ramon</forename><surname>Rene</surname></persName><roleName type="degree">PhD</roleName><affiliation>Dementia Unit, Department of Neurology, Bellvitge University Hospital, Barcelona, Spain</affiliation></author><author><persName><forename type="first">Blanca</forename><surname>Ramirez‐Ruiz</surname></persName><roleName type="degree">PhD</roleName><affiliation>Department of Psychiatry and Clinical Psychobiology, University of Barcelona, IDIBAPS, Barcelona, Spain</affiliation></author><author><persName><forename type="first">Jaume</forename><surname>Campdelacreu</surname></persName><roleName type="degree">PhD</roleName><affiliation>Dementia Unit, Department of Neurology, Bellvitge University Hospital, Barcelona, Spain</affiliation></author><author><persName><forename type="first">Jordi</forename><surname>Gascon</surname></persName><roleName type="degree">MD</roleName><affiliation>Dementia Unit, Department of Neurology, Bellvitge University Hospital, Barcelona, Spain</affiliation></author><author><persName><forename type="first">Carles</forename><surname>Falcon</surname></persName><roleName type="degree">PhD</roleName><affiliation>Image Analysis Unit, IDIBAPS, CIBER‐BBN, Physiological Science Department, University of Barcelona, Barcelona, Spain</affiliation></author><author><persName><forename type="first">Matilde</forename><surname>Calopa</surname></persName><roleName type="degree">PhD</roleName><affiliation>Movement Disorders Unit, Department of Neurology, Bellvitge University Hospital, Barcelona, Spain</affiliation></author><author><persName><forename type="first">Serge</forename><surname>Jauma</surname></persName><roleName type="degree">MD</roleName><affiliation>Movement Disorders Unit, Department of Neurology, Bellvitge University Hospital, Barcelona, Spain</affiliation></author><author><persName><forename type="first">Montserrat</forename><surname>Juncadella</surname></persName><roleName type="degree">PhD</roleName><affiliation>Dementia Unit, Department of Neurology, Bellvitge University Hospital, Barcelona, Spain</affiliation></author><author><persName><forename type="first">Carme</forename><surname>Junque</surname></persName><roleName type="degree">PhD</roleName><note type="correspondence"><p>Correspondence: Departament de Psiquiatria i Psicobiologia Clínica, Facultat de Medicina – Universitat de Barcelona, C/ Casanova, 143 08036 Barcelona, Spain</p></note><affiliation>Department of Psychiatry and Clinical Psychobiology, University of Barcelona, IDIBAPS, Barcelona, Spain</affiliation></author></analytic><monogr><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. 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The purpose of this study was to investigate the pattern of gray matter and cognitive impairment underlying VH in DLB and PDD. We applied voxel‐based morphometry and behavioral assessment to 12 clinically diagnosed DLB patients and 15 PDD patients. Subjects with VH showed greater gray matter loss than non‐hallucinators, specifically in the right inferior frontal gyrus (BA 45) in the DLB patients and in the left orbitofrontal lobe (BA 10) in the PDD patients. Comparing the two subgroups with VH, DLB patients had greater decrease of the bilateral premotor area (BA 6) than PDD patients. Furthermore, decreased volume in associative visual areas, namely left precuneus and inferior frontal lobe, correlated with VH in the DLB but not in PDD patients. VH were related to impaired verbal fluency, inhibitory control of attention and visuoperception in the DLB group and to visual memory in the PDD group. In conclusion, DLB and PDD patients with VH had more frontal gray matter atrophy than non‐hallucinators, the impairment being greater in the DLB group. The patterns of structural and functional correlations were different in both pathologies. © 2010 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>visual hallucinations</term></item><item><term>dementia</term></item><item><term>Lewy Body disease</term></item><item><term>Parkinson's disease</term></item><item><term>MRI</term></item><item><term>VBM</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>article category</head><item><term>Research Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2009-06-26">Received</change><change when="2009-10-10">Registration</change><change when="2010-04-15">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/8AB3E1F2E6A5077028126E8A376035630A9A4C85/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="short">Mov. Disord.</title></titleGroup></publicationMeta><publicationMeta level="part" position="50"><doi origin="wiley" registered="yes">10.1002/mds.v25:5</doi><numberingGroup><numbering type="journalVolume" number="25">25</numbering><numbering type="journalIssue">5</numbering></numberingGroup><coverDate startDate="2010-04-15">15 April 2010</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="140" status="forIssue"><doi origin="wiley" registered="yes">10.1002/mds.22873</doi><idGroup><id type="unit" value="MDS22873"></id></idGroup><countGroup><count type="pageTotal" number="8"></count></countGroup><titleGroup><title type="articleCategory">Research Article</title><title type="tocHeading1">Research Articles</title></titleGroup><copyright ownership="thirdParty">Copyright © 2010 Movement Disorder Society</copyright><eventGroup><event type="manuscriptReceived" date="2009-06-26"></event><event type="manuscriptRevised" date="2009-08-29"></event><event 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href="file:MDS.MDS22873.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="2"></count><count type="tableTotal" number="3"></count><count type="referenceTotal" number="48"></count><count type="wordTotal" number="5799"></count></countGroup><titleGroup><title type="main" xml:lang="en">Frontal and associative visual areas related to visual hallucinations in dementia with Lewy bodies and Parkinson's disease with dementia<link href="#fn1"></link></title><title type="short" xml:lang="en">Visual Areas Related to VH in DLB and PDD</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1 #af2"><personName><givenNames>Cristina</givenNames><familyName>Sanchez‐Castaneda</familyName><degrees>MSc</degrees></personName></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Ramon</givenNames><familyName>Rene</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Blanca</givenNames><familyName>Ramirez‐Ruiz</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Jaume</givenNames><familyName>Campdelacreu</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Jordi</givenNames><familyName>Gascon</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Carles</givenNames><familyName>Falcon</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au7" creatorRole="author" affiliationRef="#af4"><personName><givenNames>Matilde</givenNames><familyName>Calopa</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au8" creatorRole="author" affiliationRef="#af4"><personName><givenNames>Serge</givenNames><familyName>Jauma</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au9" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Montserrat</givenNames><familyName>Juncadella</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au10" creatorRole="author" affiliationRef="#af2" corresponding="yes"><personName><givenNames>Carme</givenNames><familyName>Junque</familyName><degrees>PhD</degrees></personName><contactDetails><email>cjunque@ub.edu</email></contactDetails></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="ES" type="organization"><unparsedAffiliation>Dementia Unit, Department of Neurology, Bellvitge University Hospital, Barcelona, Spain</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="ES" type="organization"><unparsedAffiliation>Department of Psychiatry and Clinical Psychobiology, University of Barcelona, IDIBAPS, Barcelona, Spain</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="ES" type="organization"><unparsedAffiliation>Image Analysis Unit, IDIBAPS, CIBER‐BBN, Physiological Science Department, University of Barcelona, Barcelona, Spain</unparsedAffiliation></affiliation><affiliation xml:id="af4" countryCode="ES" type="organization"><unparsedAffiliation>Movement Disorders Unit, Department of Neurology, Bellvitge University Hospital, Barcelona, Spain</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">visual hallucinations</keyword><keyword xml:id="kwd2">dementia</keyword><keyword xml:id="kwd3">Lewy Body disease</keyword><keyword xml:id="kwd4">Parkinson's disease</keyword><keyword xml:id="kwd5">MRI</keyword><keyword xml:id="kwd6">VBM</keyword></keywordGroup><fundingInfo><fundingAgency>la Caixa Foundation</fundingAgency><fundingNumber>2005 SGR 00855</fundingNumber></fundingInfo><fundingInfo><fundingAgency>Generalitat de Catalunya</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Center of Biomedic Investigation in Neurodegenerative Diseases (CIBERNED)</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Biomedical Investigation Institute from the Bellvitge University Hospital</fundingAgency></fundingInfo><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>Visual Hallucinations (VH) are among the core features of Dementia with Lewy Bodies (DLB), but are also very frequent in demented patients with Parkinson's Disease (PDD). The purpose of this study was to investigate the pattern of gray matter and cognitive impairment underlying VH in DLB and PDD. We applied voxel‐based morphometry and behavioral assessment to 12 clinically diagnosed DLB patients and 15 PDD patients. Subjects with VH showed greater gray matter loss than non‐hallucinators, specifically in the right inferior frontal gyrus (BA 45) in the DLB patients and in the left orbitofrontal lobe (BA 10) in the PDD patients. Comparing the two subgroups with VH, DLB patients had greater decrease of the bilateral premotor area (BA 6) than PDD patients. Furthermore, decreased volume in associative visual areas, namely left precuneus and inferior frontal lobe, correlated with VH in the DLB but not in PDD patients. VH were related to impaired verbal fluency, inhibitory control of attention and visuoperception in the DLB group and to visual memory in the PDD group. In conclusion, DLB and PDD patients with VH had more frontal gray matter atrophy than non‐hallucinators, the impairment being greater in the DLB group. The patterns of structural and functional correlations were different in both pathologies. © 2010 Movement Disorder Society</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn1"><p>Potential conflict of interest: None reported.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Frontal and associative visual areas related to visual hallucinations in dementia with Lewy bodies and Parkinson's disease with dementia</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Visual Areas Related to VH in DLB and PDD</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Frontal and associative visual areas related to visual hallucinations in dementia with Lewy bodies and Parkinson's disease with dementia</title></titleInfo><name type="personal"><namePart type="given">Cristina</namePart><namePart type="family">Sanchez‐Castaneda</namePart><namePart type="termsOfAddress">MSc</namePart><affiliation>Dementia Unit, Department of Neurology, Bellvitge University Hospital, Barcelona, Spain</affiliation><affiliation>Department of Psychiatry and Clinical Psychobiology, University of Barcelona, IDIBAPS, Barcelona, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ramon</namePart><namePart type="family">Rene</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Dementia Unit, Department of Neurology, Bellvitge University Hospital, Barcelona, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Blanca</namePart><namePart type="family">Ramirez‐Ruiz</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Psychiatry and Clinical Psychobiology, University of Barcelona, IDIBAPS, Barcelona, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jaume</namePart><namePart type="family">Campdelacreu</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Dementia Unit, Department of Neurology, Bellvitge University Hospital, Barcelona, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jordi</namePart><namePart type="family">Gascon</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Dementia Unit, Department of Neurology, Bellvitge University Hospital, Barcelona, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Carles</namePart><namePart type="family">Falcon</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Image Analysis Unit, IDIBAPS, CIBER‐BBN, Physiological Science Department, University of Barcelona, Barcelona, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Matilde</namePart><namePart type="family">Calopa</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Movement Disorders Unit, Department of Neurology, Bellvitge University Hospital, Barcelona, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Serge</namePart><namePart type="family">Jauma</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Movement Disorders Unit, Department of Neurology, Bellvitge University Hospital, Barcelona, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Montserrat</namePart><namePart type="family">Juncadella</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Dementia Unit, Department of Neurology, Bellvitge University Hospital, Barcelona, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Carme</namePart><namePart type="family">Junque</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Psychiatry and Clinical Psychobiology, University of Barcelona, IDIBAPS, Barcelona, Spain</affiliation><description>Correspondence: Departament de Psiquiatria i Psicobiologia Clínica, Facultat de Medicina – Universitat de Barcelona, C/ Casanova, 143 08036 Barcelona, Spain</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2010-04-15</dateIssued><dateCaptured encoding="w3cdtf">2009-06-26</dateCaptured><dateValid encoding="w3cdtf">2009-10-10</dateValid><copyrightDate encoding="w3cdtf">2010</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">2</extent><extent unit="tables">3</extent><extent unit="references">48</extent><extent unit="words">5799</extent></physicalDescription><abstract lang="en">Visual Hallucinations (VH) are among the core features of Dementia with Lewy Bodies (DLB), but are also very frequent in demented patients with Parkinson's Disease (PDD). The purpose of this study was to investigate the pattern of gray matter and cognitive impairment underlying VH in DLB and PDD. We applied voxel‐based morphometry and behavioral assessment to 12 clinically diagnosed DLB patients and 15 PDD patients. Subjects with VH showed greater gray matter loss than non‐hallucinators, specifically in the right inferior frontal gyrus (BA 45) in the DLB patients and in the left orbitofrontal lobe (BA 10) in the PDD patients. Comparing the two subgroups with VH, DLB patients had greater decrease of the bilateral premotor area (BA 6) than PDD patients. Furthermore, decreased volume in associative visual areas, namely left precuneus and inferior frontal lobe, correlated with VH in the DLB but not in PDD patients. VH were related to impaired verbal fluency, inhibitory control of attention and visuoperception in the DLB group and to visual memory in the PDD group. In conclusion, DLB and PDD patients with VH had more frontal gray matter atrophy than non‐hallucinators, the impairment being greater in the DLB group. The patterns of structural and functional correlations were different in both pathologies. © 2010 Movement Disorder Society</abstract><note type="content">*Potential conflict of interest: None reported.</note><note type="funding">la Caixa Foundation - No. 2005 SGR 00855; </note><note type="funding">Generalitat de Catalunya</note><note type="funding">Center of Biomedic Investigation in Neurodegenerative Diseases (CIBERNED)</note><note type="funding">Biomedical Investigation Institute from the Bellvitge University Hospital</note><subject lang="en"><genre>Keywords</genre><topic>visual hallucinations</topic><topic>dementia</topic><topic>Lewy Body disease</topic><topic>Parkinson's disease</topic><topic>MRI</topic><topic>VBM</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><genre type="Journal">journal</genre><subject><genre>article category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>25</number></detail><detail type="issue"><caption>no.</caption><number>5</number></detail><extent unit="pages"><start>615</start><end>622</end><total>8</total></extent></part></relatedItem><identifier type="istex">8AB3E1F2E6A5077028126E8A376035630A9A4C85</identifier><identifier type="DOI">10.1002/mds.22873</identifier><identifier type="ArticleID">MDS22873</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2010 Movement Disorder Society</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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